Upstream Bio Inc [UPB] stock prices are up 6.42% to $31.66 at the moment. One of the good ways to gauge the recent performance is if the stock’s short-term value is rising or falling. The UPB shares have gain 21.16% over the last week, with a monthly amount glided 10.43%, and seem to be holding up well over a long-time horizon.
From an analyst’s perspective:
Upstream Bio Inc [NASDAQ: UPB] stock has seen the most recent analyst activity on December 18, 2025, when Mizuho initiated its Outperform rating and assigned the stock a price target of $51. Previously, Evercore ISI started tracking the stock with Outperform rating on November 18, 2025, and set its price target to $40. On October 14, 2025, Truist initiated with a Buy rating and assigned a price target of $47 on the stock. William Blair started tracking the stock assigning an Outperform rating. TD Cowen initiated its recommendation with a Buy. Piper Sandler started tracking with an Overweight rating for this stock on November 05, 2024, and assigned it a price target of $75. In a note dated November 05, 2024, JP Morgan initiated an Overweight rating and provided a target price of $38 on this stock.
The stock price of Upstream Bio Inc [UPB] has been fluctuating between $5.14 and $30.89 over the past year. Currently, Wall Street analysts expect the stock to reach $49 within the next 12 months. Upstream Bio Inc [NASDAQ: UPB] shares were valued at $31.66 at the most recent close of the market. An investor can expect a potential return of 54.77% based on the average UPB price forecast.
Analyzing the UPB fundamentals
The Upstream Bio Inc [NASDAQ:UPB] reported sales of 2.80M for trailing twelve months, representing a surge of 12.52%. Gross Profit Margin for this corporation currently stands at 1.0% with Operating Profit Margin at -44.65%, Pretax Profit Margin comes in at -38.37%, and Net Profit Margin reading is -38.37%. To continue investigating profitability, this company’s Return on Assets is posted at -0.25, Equity is -0.36 and Total Capital is -0.3. Upon thorough examination of the company’s fundamental financial framework, it becomes apparent that the debt-to-equity ratio stands at 0.0.
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Ratios To Look Out For
It’s worth pointing out that Upstream Bio Inc [NASDAQ:UPB]’s Current Ratio is 32.67. Also, the Quick Ratio is 32.67, while the Cash Ratio stands at 4.16. Considering the valuation of this stock, the price to sales ratio is 611.02, the price to book ratio is 4.52.
