Septerna Inc [SEPN] stock is trading at $23.26, up 20.92%. One of the good ways to gauge the recent performance is if the stock’s short-term value is rising or falling. The SEPN shares have gain 25.69% over the last week, with a monthly amount glided 3.10%, and seem to be holding up well over a long-time horizon.
From an analyst’s perspective:
Septerna Inc [NASDAQ: SEPN] stock has seen the most recent analyst activity on November 14, 2025, when Wells Fargo upgraded its rating to a Overweight. Previously, H.C. Wainwright started tracking the stock with Buy rating on June 23, 2025, and set its price target to $26. On February 18, 2025, downgrade downgraded it’s rating to Equal Weight but maintained its price target of $14 on the stock. Wells Fargo started tracking the stock assigning a Overweight rating and suggested a price target of $43 on November 19, 2024. TD Cowen initiated its recommendation with a Buy. JP Morgan started tracking with a Overweight rating for this stock on November 19, 2024, and assigned it a price target of $38. In a note dated November 19, 2024, Cantor Fitzgerald initiated an Overweight rating and provided a target price of $50 on this stock.
Septerna Inc [SEPN] stock has fluctuated between $4.17 and $28.99 over the past year. Currently, Wall Street analysts expect the stock to reach $28 within the next 12 months. Septerna Inc [NASDAQ: SEPN] shares were valued at $23.26 at the most recent close of the market. An investor can expect a potential return of 20.38% based on the average SEPN price forecast.
Analyzing the SEPN fundamentals
Septerna Inc [NASDAQ:SEPN] reported sales of 22.05M for the trailing twelve months, which represents a growth of 12113.07%. Gross Profit Margin for this corporation currently stands at 0.02% with Operating Profit Margin at -3.49%, Pretax Profit Margin comes in at -2.67%, and Net Profit Margin reading is -2.67%. To continue investigating profitability, this company’s Return on Assets is posted at -0.1, Equity is -0.15 and Total Capital is -0.14. An extended analysis of the company’s primary financial structure reveals a debt-to-equity ratio of0.06.
Before buying any particular stock, readers tend to pay close attention to the indicators that support and create resistance. The company’s stock is currently sitting at 20.64 points at the first support level, and at 18.02 for the second support level. However, for the 1st resistance point, the stock is sitting at 24.94, and for the 2nd resistance point, it is at 26.61.
Ratios To Look Out For
For context, Septerna Inc’s Current Ratio is 6.53. Also, the Quick Ratio is 6.53, while the Cash Ratio stands at 4.25. Considering the valuation of this stock, the price to sales ratio is 47.24, the price to book ratio is 2.67.
Transactions by insiders
Recent insider trading involved Long Daniel D., SVP, Drug Discovery, that happened on Nov 10 ’25 when 3501.0 shares were sold. Officer, DANIEL DAVID LONG completed a deal on Nov 10 ’25 to buy 3501.0 shares. Meanwhile, Director Ezekowitz Alan bought 13319.0 shares on Mar 07 ’25.
