A share price of Ionis Pharmaceuticals Inc [IONS] is currently trading at $81.79, up 2.96%. An important factor to consider is whether the stock is rising or falling in short-term value. The IONS shares have gain 3.70% over the last week, with a monthly amount glided 2.79%, and seem to be holding up well over a long-time horizon.
From an analyst’s perspective:
Ionis Pharmaceuticals Inc [NASDAQ: IONS] stock has seen the most recent analyst activity on October 08, 2025, when JP Morgan upgraded its rating to an Overweight but kept the price target unchanged to $80 for it. Previously, Goldman upgraded its rating to Neutral on September 26, 2025, and kept the price target unchanged to $65. On September 03, 2025, upgrade upgraded it’s rating to Outperform but maintained its price target of $70 on the stock. Morgan Stanley upgraded its rating to an Overweight but stick to its price target of $62 on July 31, 2025. Barclays upgraded its rating to an Overweight but $57 remained the price target by the analyst firm on July 01, 2025. H.C. Wainwright started tracking with a Buy rating for this stock on April 07, 2025, and assigned it a price target of $45. In a note dated March 31, 2025, Redburn Atlantic initiated a Neutral rating and provided a target price of $39 on this stock.
Ionis Pharmaceuticals Inc experienced fluctuations in its stock price throughout the past year between $23.95 and $86.15. Currently, Wall Street analysts expect the stock to reach $87.36 within the next 12 months. Ionis Pharmaceuticals Inc [NASDAQ: IONS] shares were valued at $81.79 at the most recent close of the market. An investor can expect a potential return of 6.81% based on the average IONS price forecast.
Analyzing the IONS fundamentals
Trailing Twelve Months sales for Ionis Pharmaceuticals Inc [NASDAQ:IONS] were 967.38M which represents 17.12% growth. Gross Profit Margin for this corporation currently stands at 0.99% with Operating Profit Margin at -0.29%, Pretax Profit Margin comes in at -0.27%, and Net Profit Margin reading is -0.27%. To continue investigating profitability, this company’s Return on Assets is posted at -0.08, Equity is -0.44 and Total Capital is -0.13. Upon thorough examination of the company’s fundamental financial framework, it becomes apparent that the debt-to-equity ratio stands at 2.41.
Before buying any particular stock, readers tend to pay close attention to the indicators that support and create resistance.
Ratios To Look Out For
To put it in perspective, the Current Ratio for Ionis Pharmaceuticals Inc [NASDAQ:IONS] is 2.79. On the other hand, the Quick Ratio is 2.78, and the Cash Ratio is 0.37. Considering the valuation of this stock, the price to sales ratio is 13.69, the price to book ratio is 21.33.
Transactions by insiders
Recent insider trading involved Devers Shannon L., Officer, that happened on Jan 22 ’26 when 3977.0 shares were purchased. Member of immediate family of, Baroldi Mariana completed a deal on Jan 16 ’26 to buy 1171.0 shares. Meanwhile, EVP Research Swayze Eric sold 9884.0 shares on Jan 16 ’26.
