A share price of Spyre Therapeutics Inc [SYRE] is currently trading at $31.53, down -3.87%. An important factor to consider is whether the stock is rising or falling in short-term value. The SYRE shares have gain 3.96% over the last week, with a monthly amount drifted -8.24%, and not seem to be holding up well over a long-time horizon.
From an analyst’s perspective:
Spyre Therapeutics Inc [NASDAQ: SYRE] stock has seen the most recent analyst activity on December 18, 2025, when Mizuho initiated its Outperform rating and assigned the stock a price target of $53. Previously, Citigroup started tracking the stock with Buy rating on December 17, 2025, and set its price target to $64. On September 26, 2025, Deutsche Bank initiated with a Buy rating and assigned a price target of $43 on the stock. Leerink Partners started tracking the stock assigning an Outperform rating and suggested a price target of $45 on April 08, 2025. Wolfe Research initiated its recommendation with an Outperform and recommended $27 as its price target on March 18, 2025. Wedbush started tracking with an Outperform rating for this stock on September 04, 2024, and assigned it a price target of $45. In a note dated July 16, 2024, Evercore ISI initiated an Outperform rating.
Spyre Therapeutics Inc experienced fluctuations in its stock price throughout the past year between $10.91 and $35.31. Currently, Wall Street analysts expect the stock to reach $48 within the next 12 months. Spyre Therapeutics Inc [NASDAQ: SYRE] shares were valued at $31.53 at the most recent close of the market. An investor can expect a potential return of 52.24% based on the average SYRE price forecast.
Analyzing the SYRE fundamentals
To continue investigating profitability, this company’s Return on Assets is posted at -0.3, Equity is -0.31 and Total Capital is -0.47.
Before buying any particular stock, readers tend to pay close attention to the indicators that support and create resistance.
Ratios To Look Out For
To put it in perspective, the Current Ratio for Spyre Therapeutics Inc [NASDAQ:SYRE] is 10.90. On the other hand, the Quick Ratio is 10.90, and the Cash Ratio is 1.4.
Transactions by insiders
Recent insider trading involved Turtle Cameron, Chief Executive Officer, that happened on Jan 02 ’26 when 15000.0 shares were sold. Chief Executive Officer, Turtle Cameron completed a deal on Dec 01 ’25 to sell 15000.0 shares. Meanwhile, Chief Executive Officer Turtle Cameron sold 45000.0 shares on Nov 03 ’25.
