Septerna Inc [SEPN] stock is trading at $29.58, up 7.41%. Until recently, the best way to gauge how the stock has performed was to look at its short-term value. The SEPN shares have gain 16.27% over the last week, with a monthly amount glided 28.05%, and seem to be holding up well over a long-time horizon.
From an analyst’s perspective:
Septerna Inc [NASDAQ: SEPN] stock has seen the most recent analyst activity on December 19, 2025, when Raymond James initiated its Strong Buy rating and assigned the stock a price target of $38. Previously, Truist started tracking the stock with Buy rating on December 15, 2025, and set its price target to $34. On November 14, 2025, upgrade upgraded it’s rating to Overweight. H.C. Wainwright started tracking the stock assigning a Buy rating and suggested a price target of $26 on June 23, 2025. Wells Fargo downgraded its rating to a Equal Weight but $14 remained the price target by the analyst firm on February 18, 2025. Wells Fargo started tracking with a Overweight rating for this stock on November 19, 2024, and assigned it a price target of $43. In a note dated November 19, 2024, TD Cowen initiated an Buy rating.
Septerna Inc [SEPN] stock has fluctuated between $4.17 and $29.74 over the past year. Currently, Wall Street analysts expect the stock to reach $33.33 within the next 12 months. Septerna Inc [NASDAQ: SEPN] shares were valued at $29.58 at the most recent close of the market. An investor can expect a potential return of 12.68% based on the average SEPN price forecast.
Analyzing the SEPN fundamentals
Septerna Inc [NASDAQ:SEPN] reported sales of 22.05M for the trailing twelve months, which represents a growth of 12113.07%. Gross Profit Margin for this corporation currently stands at 0.02% with Operating Profit Margin at -3.49%, Pretax Profit Margin comes in at -2.67%, and Net Profit Margin reading is -2.67%. To continue investigating profitability, this company’s Return on Assets is posted at -0.1, Equity is -0.15 and Total Capital is -0.14. An extended analysis of the company’s primary financial structure reveals a debt-to-equity ratio of0.06.
Before buying any particular stock, readers tend to pay close attention to the indicators that support and create resistance. The company’s stock is currently sitting at 28.55 points at the first support level, and at 27.53 for the second support level. However, for the 1st resistance point, the stock is sitting at 30.55, and for the 2nd resistance point, it is at 31.53.
Ratios To Look Out For
For context, Septerna Inc’s Current Ratio is 6.53. As well, the Quick Ratio is 6.53, while the Cash Ratio is 4.25. Considering the valuation of this stock, the price to sales ratio is 60.06, the price to book ratio is 3.40.
Transactions by insiders
Recent insider trading involved Long Daniel D., SVP, Drug Discovery, that happened on Nov 10 ’25 when 3501.0 shares were sold. Officer, DANIEL DAVID LONG completed a deal on Nov 10 ’25 to buy 3501.0 shares. Meanwhile, Director Ezekowitz Alan bought 13319.0 shares on Mar 07 ’25.
