Septerna Inc (SEPN) Shares on the Decline: Short-term Analysis

Septerna Inc [SEPN] stock is trading at $15.7, down -1.51%. An important factor to consider is whether the stock is rising or falling in short-term value. The SEPN shares have gain 9.94% over the last week, with a monthly amount glided 41.57%, and seem to be holding up well over a long-time horizon.

From an analyst’s perspective:

Septerna Inc [NASDAQ: SEPN] stock has seen the most recent analyst activity on June 23, 2025, when H.C. Wainwright initiated its Buy rating and assigned the stock a price target of $26. Previously, Wells Fargo downgraded its rating to Equal Weight on February 18, 2025, and kept the price target unchanged to $14. On November 19, 2024, Wells Fargo initiated with a Overweight rating and assigned a price target of $43 on the stock. TD Cowen started tracking the stock assigning a Buy rating. JP Morgan initiated its recommendation with a Overweight and recommended $38 as its price target on November 19, 2024. Cantor Fitzgerald started tracking with a Overweight rating for this stock on November 19, 2024, and assigned it a price target of $50.

Septerna Inc [SEPN] stock has fluctuated between $4.17 and $28.99 over the past year. Currently, Wall Street analysts expect the stock to reach $18 within the next 12 months. Septerna Inc [NASDAQ: SEPN] shares were valued at $15.7 at the most recent close of the market. An investor can expect a potential return of 14.65% based on the average SEPN price forecast.

Analyzing the SEPN fundamentals

Septerna Inc [NASDAQ:SEPN] reported sales of 0.73M for the trailing twelve months, which represents a drop of -67.84%. Gross Profit Margin for this corporation currently stands at 0.84% with Operating Profit Margin at -140.71%, Pretax Profit Margin comes in at -120.94%, and Net Profit Margin reading is -120.53%. To continue investigating profitability, this company’s Return on Assets is posted at -0.21, Equity is -0.32 and Total Capital is -0.26. Upon thorough examination of the company’s fundamental financial framework, it becomes apparent that the debt-to-equity ratio stands at 0.07.

Before buying any particular stock, readers tend to pay close attention to the indicators that support and create resistance.

Ratios To Look Out For

For context, Septerna Inc’s Current Ratio is 22.09. On the other hand, the Quick Ratio is 22.09, and the Cash Ratio is 12.51. Considering the valuation of this stock, the price to sales ratio is 958.89, the price to book ratio is 1.85.

Transactions by insiders

Recent insider trading involved Ezekowitz Alan, Director, that happened on Mar 07 ’25 when 13319.0 shares were purchased. Director, Ezekowitz Alan completed a deal on Mar 06 ’25 to buy 41355.0 shares. Meanwhile, Director Ezekowitz Alan bought 37835.0 shares on Mar 05 ’25.

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