How much can investors make with Prime Medicine Inc (PRME) stock in the next 12 months?

Prime Medicine Inc [PRME] stock is trading at $3.46, down -1.42%. An important factor to consider is whether the stock is rising or falling in short-term value. The PRME shares have lost -20.82% over the last week, with a monthly amount drifted -27.99%, and not seem to be holding up well over a long-time horizon.

From an analyst’s perspective:

Prime Medicine Inc [NASDAQ: PRME] stock has seen the most recent analyst activity on May 27, 2025, when Citigroup downgraded its rating to a Neutral but kept the price target unchanged to $1.50 for it. Previously, JP Morgan downgraded its rating to Neutral on May 20, 2025. On May 20, 2025, downgrade downgraded it’s rating to Neutral. JMP Securities started tracking the stock assigning a Mkt Outperform rating and suggested a price target of $10 on December 10, 2024. H.C. Wainwright initiated its recommendation with a Buy and recommended $10 as its price target on May 20, 2024. Citigroup upgraded its rating to Buy for this stock on May 16, 2024, but kept the price target unchanged to $10. In a note dated April 22, 2024, Chardan Capital Markets initiated an Buy rating and provided a target price of $17 on this stock.

Prime Medicine Inc [PRME] stock has fluctuated between $1.11 and $5.17 over the past year. Currently, Wall Street analysts expect the stock to reach $17.25 within the next 12 months. Prime Medicine Inc [NASDAQ: PRME] shares were valued at $3.46 at the most recent close of the market. An investor can expect a potential return of 398.55% based on the average PRME price forecast.

Analyzing the PRME fundamentals

Gross Profit Margin for this corporation currently stands at 0.78% with Operating Profit Margin at -41.17%, Pretax Profit Margin comes in at -40.17%, and Net Profit Margin reading is -40.17%. To continue investigating profitability, this company’s Return on Assets is posted at -0.71, Equity is -1.56 and Total Capital is -0.83. Upon thorough examination of the company’s fundamental financial framework, it becomes apparent that the debt-to-equity ratio stands at 1.97.

Before buying any particular stock, readers tend to pay close attention to the indicators that support and create resistance. The company’s stock is currently sitting at 3.31 points at the first support level, and at 3.16 for the second support level. However, for the 1st resistance point, the stock is sitting at 3.65, and for the 2nd resistance point, it is at 3.84.

Ratios To Look Out For

For context, Prime Medicine Inc’s Current Ratio is 3.56. On the other hand, the Quick Ratio is 3.56, and the Cash Ratio is 1.58. Considering the valuation of this stock, the price to sales ratio is 124.31, the price to book ratio is 7.65.

Transactions by insiders

Recent insider trading involved GV 2021 GP, L.L.C., 10% Owner, that happened on Aug 01 ’25 when 1.5 million shares were purchased. Director, NELSEN ROBERT completed a deal on Aug 01 ’25 to buy 3.03 million shares. Meanwhile, 10% Owner ARCH Venture Partners XII, LLC bought 3.03 million shares on Aug 01 ’25.

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